Lymphocyte Transformation in Immunoproliferative Disorders
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چکیده
منابع مشابه
EFFECT OF aIFN ON UNAGGRESSIVE IMMUNOPROLIFERATIVE DISORDERS
Background. a-IFN is reported to be an effective treatment for a number of lymphoproliferative diseases. Little information is available at present on its effect in unaggressive immunoproliferative disorders. Study design and results. In a prospective non randomized study, 57 patients with IgG or IgA MGUS, smouldering myeloma or stage I MM treated with a-IFN (3 MU 3 times a week for at least 6 ...
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Selimeyer, E., Bhettay, E., Truswell, A. S., Meyers, 0. L., and Hansen, J. D. L. (1972). Archives of Disease in Childhood, 47, 429. Lymphocyte transformation in malnourished children. In vitro lymphocyte stimulation with phytohaemagglutinin gave subnormal transformation values in children with proteincalorie malnutrition. It is suggested that impaired cell-mediated immunity may be one important...
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Current techniques for lymphocyte transformation are evaluated and criticised. A simple technique, designed to meet these criticisms, is described in detail, with particular reference to lymphocyte separation and scoring methods.
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Malignant B cells may originate from any of the stages of differentiation of B cells, primarily from IgM bearing B cells. The malignant B cells maintain a limited potential for differentiation. In addition to surface immunoglobulins, various markers may be present on the B cell surface; when surface Ig cannot be identified, these markers are used to identify B cells. However, for practical purp...
متن کاملAerobic glycolysis and lymphocyte transformation.
1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-(14)C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1972
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1972.22